Endurance Run started with Jeff and Vinny playing through Persona 4 back in 2009 and earned a legendary status among Giant Bomb fans. Second season started in 2010 with two concurrent playthroughs of Deadly Premonition by the original cast and Brad and Ryan. The series returned for the last time in 2012 with Ryan and Patrick playing Chrono Trigger.
They will never do another one. They did!